Cat No.：31330 ★Download Datasheet★ ★MSDS★
INTRODUCTION
Neutrophil elastase (NE), also known as leukocyte elastase, serine elastase, and elaszym, is one of the hematopoietic serine proteases localized in the primary granules of polymorphonuclear neutrophils (PMNs). The primary function of NE is
recognized as to participate in the clearance of invaded pathogens through its intracellular and extracellular killing as well as antimicrobial activity, and the degradation of extracellular matrix components, including elastin, collagens, fibroncetin
and proteoglycans.
Assay Characteristics:
Sample Type: Serum and plasma
Publications Citing This Product
1. Elie AG, Bloksgaard M, Sun WY, Yang K, Man AW, Xu A, Irmukhamedov A, Riber LP, Wang Y, De Mey JG. Local enrichment of fatty acid-binding
protein 4 in the pericardial cavity of cardiovascular disease patients. PloS one. 2018 Nov 5;13(11):e0206802.
2. Qian LL, Wu L, Zhang L, Zhang J, Zhou J, Li YH, Fang QC, Li HT, Jia WP. Serum biomarkers combined with ultrasonography for early
diagnosis of non-alcoholic fatty liver disease confirmed by magnetic resonance spectroscopy. Acta Pharmacologica Sinica.
2020 Apr;41(4):554-60.
3. Ong KL, Wu L, Januszewski AS, O’Connell R, Xu A, Scott RS, Sullivan DR, Rye KA, Li H, Ma RC, Li L. The relationship of neutrophil elastase and
proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD)
sub-study. Diabetes and Vascular Disease Research. 2021 Jul;18(4):14791641211032547.
References:
1. Wang, Yudong, et al. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes. 2014; 63(12):4239-48.